DESCRIPTION of "Differin, gel 0.1% 30g"
Pharmacological action

Adapalene represents a new generation of synthetic retinoids and is a derivative of the naphthoic acid. Adapalene has sebostaticheskim, komedonoliticheskim / antikomedogennym and anti-inflammatory action.
The drug affects the follicular hyperkeratosis, regulating the process of keratinization and desquamation - has expressed komedonoliticheskoy activity (impact on the open and closed comedones) and antikomedogennym action (prevents the formation of mikrokomedonov).
The main mechanism of action - selective binding with nuclear RAg-receptor cells of the epidermis unlike non-selective binding of synthetic retinoids of the previous generations. This mechanism regulates the final differentiation of keratinocytes, which provides the normalization of the process of keratinization and the reduction of the conditions for the creation of mikrokomedonov.
Proven pronounced anti-inflammatory effect of adapalene: inhibition of lipoxygenase, arihidonovoy acid, cytokines. In vitro and In vivo shows high anti-inflammatory activity, comparable in effectiveness with betamethasone and indomethacin, through the influence of the factors of inflammation.
Adapalene has photosensitizing action.

The Pharmacokinetics Of

Due to the low systemic absorption of the data on the pharmacokinetics of the drug Differin are not available.

Indications

- Acne.

The dosage

A cream or gel evenly, not rubbing, applied on the affected areas of skin once a day at bedtime. The drug should be applied to clean, dry skin.
The therapeutic effect develops after 4-8 weeks of therapy, the steady improvements - within three months from the beginning of therapy.
May repeat courses of therapy product on the recommendation of a doctor.
Differin cream is recommended for sensitive and dry skin.

Side effect

Local reactions: in case of applying a cream or gel in excessive amounts possible redness and peeling of the skin.

Contraindications

- Increased sensitivity to components of the preparation.

Pregnancy and lactation

Differin are not recommended for use in pregnancy and lactation (breast-feeding).

Special instructions

When use of the drug should avoid contact with eyes and lips.
In some cases, in the application of the drug may be a short-term irritation of the skin, in such cases, therapy should be interrupted until the disappearance of the signs of irritation.
In the period of application of the drug should be avoided active stay in the sun and UV radiation due to a possible slight skin irritation.
In the period of application of the preparation does not recommend the use of cosmetic products with Dries up oily or irritating effect (including spirits, etanolsoderzhaschie funds).
It is possible to use other means for the treatment of acne on the background of Differina; the Differin is used one time / day before going to sleep, and in the morning, use other means (for example, 4% lotion erythromycin, 1% lotion klindamitina, benzoyl peroxide in water-based in concentrations not exceeding 10%). Simultaneous use of makeup and moisturizers funds, which do not contribute to the formation of comedones.

Overdose

Due to the low systemic absorption overdose unlikely.

Drug interaction

Is not set clinically significant interactions of the preparation Differin while the use of klindamitina phosphate or benzoyl peroxide.

Terms and conditions of storage

Adapalene - active substance Differin, resistant to oxygen and light, chemically inactive.
The gel should be stored at a temperature of no higher than 25 C, in places inaccessible to children. Shelf life - 3 years.
The cream should be stored at a temperature of no higher than 25 C, in places inaccessible for children; do not freeze. Shelf life - 2 years.
Dispensing conditions
The drug is allowed to be used as non-prescription medicines.