Buy Lamisil (Terbinafine)
Buy Lamisil Online
Primary Information
Pharmacological action
Antifungal agent for topical use, a derivative of allylamine. Has a broad spectrum antifungal activity. At low concentrations terbinafine has a fungicidal action against dermatophytes Trichophyton (including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton violaceum, Trichophyton tonsurans), Microsporum canis and Epidermophyton floccosum, molds (mainly Candida albicans) and certain dimorphic fungi (Pityrosporum orbiculare or Malassezia furfur). Activity against yeasts, depending on their type, may be fungicidal or fungistatic.
Terbinafine specific alters sterol biosynthesis early stage, which occurs in fungi. This leads to a deficiency of ergosterol and the accumulation of intracellular squalene, which causes cell death of the fungus. The action of terbinafine carried out by inhibiting the enzyme skvalenepoksidazy, located on the cell membrane of the fungus. Skvalenepoksidaza not associated with cytochrome P450. Terbinafine does not influence the metabolism of hormones or other drugs.
Pharmacokinetics
After application of the drug Lamisil ® Uno on the skin forms a transparent solution imperceptible film which remains on the skin for 72 hours from the film terbinafine penetrates quickly into the stratum corneum of the skin: 60 minutes after the procedure, 16-18% of applied dose found in the stratum corneum. The release of terbinafine is progressive in nature, the active ingredient is present in the stratum corneum after 13 days at concentrations exceeding the minimum inhibitory concentration of terbinafine in vitro against the dermatophytes.
Systemic bioavailability is extremely low. With topical absorption of the drug less than 5%. Lamisil ® Uno has little systemic effect.
Recurrence rate after 3 months of preparation is low (no higher than 12.5%).
Indications for use of the drug Lamisil ® DNA
- Fungal infections (tinea) foot (tinea pedis).
The drug is used topically as a single dose.
Adults and adolescents older than 15 years of film-forming solution Lamisil ® Uno applied 1 time on both feet, even if the fungal infection was observed only on one foot. This ensures the elimination of fungi (dermatophytes) that may be in areas of the foot, where the lesion was not visually noticeable.
Prior to application of the drug should wash and dry feet and hands. First processed by one foot, then another. Since the procedure for interdigital areas, should apply a thin layer evenly between the fingers and around all over their surface, as well as on the sole of the foot and side to a height of 1.5 cm using enough medication to cover the required surface of the skin, usually 1 / 2 to process each foot.
This should also be treated and the other foot, even if the skin looks healthy on it. Solution was dried for 1-2 minutes until the film. After processing a stop to wash their hands.
Should not be applied to drug re-treated skin. Lamisil ® Uno should not be rubbed into the skin.
Side effect
Side effects are very rare, mild and are of short duration.
Systemic reactions: very rare (<1 / 10 000) - allergic reactions (rash, redness, dermatitis bullous and urticaria).
Local reactions: rare (> 1 / 1000, <1 / 100) - dryness, irritation or burning sensation in the treated area of skin preparation.
Contraindications to the use of the drug Lamisil ® DNA
- Hypersensitivity to terbinafine or to any of the inactive ingredients of the drug.
Precautions should be prescribed the drug for liver and / or renal failure, alcoholism, inhibition of bone marrow blood, tumors, metabolic diseases, occlusive vascular diseases of extremities, as well as children under the age of 15 years (due to lack of clinical experience).
Use of the drug Lamisil ® DNA during pregnancy and breastfeeding
Clinical experience with Lamisil Uno during pregnancy is very limited, so the product can be used only under strict indications.
It is known that terbinafine is excreted in breast milk, so the drug should not be used during breastfeeding.
In experimental studies, teratogenic terbinafine was not detected. So far, no report of any defects in the application of Lamisil Uno.
Application of human liver
Sostorozhnostyu should be prescribed the drug for liver failure.
Use in renal impairment
Sostorozhnostyu should be prescribed the drug for renal failure.
Cautions
Lamisil ® Uno is not recommended in case of chronic plantar hyperkeratosis caused by Tinea pedis (mokassinovogo type).
Lamisil ® Uno is designed for external use only. The drug should not be applied to the skin, it can cause eye irritation. In case of accidental contact with eyes, rinse them thoroughly under running water. The drug should not be taken in!
In the case of an allergic reaction to the drug film should be removed with an organic solvent (such as denatured alcohol) and then wash feet with soap and water.
With the development of allergic reactions to stop medication.
For best results, the treated area should not be washed for 24 hours after the procedure. Therefore, Lamisil ® Uno is recommended to be applied after a shower or bath and the next day again to wash his feet at the same time.
You must use this amount of drug that would be needed for film on both feet, going through the above procedure. Unused balance of the drug should be destroyed.
Improvement of clinical symptoms usually occurs within a few days. If a week is no sign of improvement, you should verify the diagnosis.
There is no evidence that the treatment of elderly patients require different doses or having other side effects than younger patients.
Use in Pediatrics
Effect of the drug Lamisil ® Uno Pediatric not been studied. Therefore, do not use the drug in children younger than 15 years.
Effects on ability to drive and control mechanisms
With topical Lamisil ® Uno does not affect the ability to drive or operate machinery to perform.
Overdose
No cases of overdose have been reported. Overdose is unlikely, because the drug is available in a quantity required for a single use and is designed for outdoor use.
Symptoms: The Accidental taking the drug into possible headache, nausea, epigastric pain and dizziness.
Treatment: appointment of activated charcoal, if necessary, symptomatic therapy in the hospital.
Drug Interactions
Currently, drug interactions terbinafine Uno is not known.
Pharmacy purchasing terms
The drug is approved for use as non-prescription medicines.
Terms and Conditions of storage
The drug should be stored at temperatures not exceeding 30 ° C in the original container out of reach of children. Shelf Life - 3 years.
Antifungal agent for topical use, a derivative of allylamine. Has a broad spectrum antifungal activity. At low concentrations terbinafine has a fungicidal action against dermatophytes Trichophyton (including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton violaceum, Trichophyton tonsurans), Microsporum canis and Epidermophyton floccosum, molds (mainly Candida albicans) and certain dimorphic fungi (Pityrosporum orbiculare or Malassezia furfur). Activity against yeasts, depending on their type, may be fungicidal or fungistatic.
Terbinafine specific alters sterol biosynthesis early stage, which occurs in fungi. This leads to a deficiency of ergosterol and the accumulation of intracellular squalene, which causes cell death of the fungus. The action of terbinafine carried out by inhibiting the enzyme skvalenepoksidazy, located on the cell membrane of the fungus. Skvalenepoksidaza not associated with cytochrome P450. Terbinafine does not influence the metabolism of hormones or other drugs.
Pharmacokinetics
After application of the drug Lamisil ® Uno on the skin forms a transparent solution imperceptible film which remains on the skin for 72 hours from the film terbinafine penetrates quickly into the stratum corneum of the skin: 60 minutes after the procedure, 16-18% of applied dose found in the stratum corneum. The release of terbinafine is progressive in nature, the active ingredient is present in the stratum corneum after 13 days at concentrations exceeding the minimum inhibitory concentration of terbinafine in vitro against the dermatophytes.
Systemic bioavailability is extremely low. With topical absorption of the drug less than 5%. Lamisil ® Uno has little systemic effect.
Recurrence rate after 3 months of preparation is low (no higher than 12.5%).
Indications for use of the drug Lamisil ® DNA
- Fungal infections (tinea) foot (tinea pedis).
The drug is used topically as a single dose.
Adults and adolescents older than 15 years of film-forming solution Lamisil ® Uno applied 1 time on both feet, even if the fungal infection was observed only on one foot. This ensures the elimination of fungi (dermatophytes) that may be in areas of the foot, where the lesion was not visually noticeable.
Prior to application of the drug should wash and dry feet and hands. First processed by one foot, then another. Since the procedure for interdigital areas, should apply a thin layer evenly between the fingers and around all over their surface, as well as on the sole of the foot and side to a height of 1.5 cm using enough medication to cover the required surface of the skin, usually 1 / 2 to process each foot.
This should also be treated and the other foot, even if the skin looks healthy on it. Solution was dried for 1-2 minutes until the film. After processing a stop to wash their hands.
Should not be applied to drug re-treated skin. Lamisil ® Uno should not be rubbed into the skin.
Side effect
Side effects are very rare, mild and are of short duration.
Systemic reactions: very rare (<1 / 10 000) - allergic reactions (rash, redness, dermatitis bullous and urticaria).
Local reactions: rare (> 1 / 1000, <1 / 100) - dryness, irritation or burning sensation in the treated area of skin preparation.
Contraindications to the use of the drug Lamisil ® DNA
- Hypersensitivity to terbinafine or to any of the inactive ingredients of the drug.
Precautions should be prescribed the drug for liver and / or renal failure, alcoholism, inhibition of bone marrow blood, tumors, metabolic diseases, occlusive vascular diseases of extremities, as well as children under the age of 15 years (due to lack of clinical experience).
Use of the drug Lamisil ® DNA during pregnancy and breastfeeding
Clinical experience with Lamisil Uno during pregnancy is very limited, so the product can be used only under strict indications.
It is known that terbinafine is excreted in breast milk, so the drug should not be used during breastfeeding.
In experimental studies, teratogenic terbinafine was not detected. So far, no report of any defects in the application of Lamisil Uno.
Application of human liver
Sostorozhnostyu should be prescribed the drug for liver failure.
Use in renal impairment
Sostorozhnostyu should be prescribed the drug for renal failure.
Cautions
Lamisil ® Uno is not recommended in case of chronic plantar hyperkeratosis caused by Tinea pedis (mokassinovogo type).
Lamisil ® Uno is designed for external use only. The drug should not be applied to the skin, it can cause eye irritation. In case of accidental contact with eyes, rinse them thoroughly under running water. The drug should not be taken in!
In the case of an allergic reaction to the drug film should be removed with an organic solvent (such as denatured alcohol) and then wash feet with soap and water.
With the development of allergic reactions to stop medication.
For best results, the treated area should not be washed for 24 hours after the procedure. Therefore, Lamisil ® Uno is recommended to be applied after a shower or bath and the next day again to wash his feet at the same time.
You must use this amount of drug that would be needed for film on both feet, going through the above procedure. Unused balance of the drug should be destroyed.
Improvement of clinical symptoms usually occurs within a few days. If a week is no sign of improvement, you should verify the diagnosis.
There is no evidence that the treatment of elderly patients require different doses or having other side effects than younger patients.
Use in Pediatrics
Effect of the drug Lamisil ® Uno Pediatric not been studied. Therefore, do not use the drug in children younger than 15 years.
Effects on ability to drive and control mechanisms
With topical Lamisil ® Uno does not affect the ability to drive or operate machinery to perform.
Overdose
No cases of overdose have been reported. Overdose is unlikely, because the drug is available in a quantity required for a single use and is designed for outdoor use.
Symptoms: The Accidental taking the drug into possible headache, nausea, epigastric pain and dizziness.
Treatment: appointment of activated charcoal, if necessary, symptomatic therapy in the hospital.
Drug Interactions
Currently, drug interactions terbinafine Uno is not known.
Pharmacy purchasing terms
The drug is approved for use as non-prescription medicines.
Terms and Conditions of storage
The drug should be stored at temperatures not exceeding 30 ° C in the original container out of reach of children. Shelf Life - 3 years.